Thermo Fisher Scientific Ataxin 7 Monoclonal Antibody (3SCA-1C1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Immunocytochemistry (ICC/IF)

1:50

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

3SCA-1C1

Immunogen

Recombinant human Ataxin 7 aa 1 - 229. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Ataxin 7,uniProtId:O15265-1,ncbiNodeId:9606,antigenRange:1-229,antigenLength:892,antigenImageFileName:MA3-083_Ataxin_7_O15265-1_House_mouse.svg,antigenImageFileNamePDP:MA3-083_Ataxin_7_O15265-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2633328

Product Specific Information

MA3-083 detects Ataxin 7 from human and mouse samples.

MA3-083 has been successfully used in Western blot, immunofluorescence, and ELISA applications.

The MA3-083 epitope is mapped between aa 66 and aa 119.

Target Information

Spinocerebellar ataxia type 7 (SCA7) belongs to a class of hereditary neurodegenrative diseases characterized by abnormally expanded polyglutamine (CAG) repeats at the N-terminus. This autosomal dominant cerebellar ataxia primarily affects the cerebellum, retina, and brain stem and causes dementia, macular degeneration and other neurodegenerative characteristics. SCA7 gene encodes the ubiquitous 892 residue protein ataxin-7. This protein is typically located in the cytoplasm and on the nuclear membrane of normal brain neurons. In cells where there is a mutation of the SCA7 gene, ataxin 7 accumulates in intranuclear inclusions and can result in cell death.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.