Thermo Fisher Scientific Ataxin 3 Monoclonal Antibody (2SCA-1H9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2SCA-1H9

Immunogen

Human Ataxin-3 fragment from aa F112-aa L249 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Ataxin 3,uniProtId:P54252-2,ncbiNodeId:9606,antigenRange:112-249,antigenLength:361,antigenImageFileName:MA3-082_Ataxin_3_P54252-2_House_mouse.svg,antigenImageFileNamePDP:MA3-082_Ataxin_3_P54252-2_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2633327

Product Specific Information

MA3-082 detects Ataxin 3 from human, mouse and rat samples.

MA3-082 has been successfully used in Western blot, immunofluorescence, and ELISA applications.

MA3-082 has been successfully used in Western blot, immunofluorescence, and ELISA applications. The MA3-082 immunogen is the human ataxin-3 fragment from aa 112 - aa L249 as a fusion protein.

Target Information

Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.