Thermo Fisher Scientific Ataxin 7 Monoclonal Antibody (3SCA-1C1)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• MA3-083 detects Ataxin 7 from human and mouse samples.
• Successfully used in Western blot, immunofluorescence, and ELISA applications.
• The epitope is mapped between amino acids 66 and 119.

Target Information

Spinocerebellar ataxia type 7 (SCA7) is a hereditary neurodegenerative disease characterized by expanded polyglutamine (CAG) repeats at the N-terminus.
This autosomal dominant cerebellar ataxia affects the cerebellum, retina, and brain stem, leading to dementia and macular degeneration.
The SCA7 gene encodes the 892-residue protein ataxin-7, typically located in the cytoplasm and on the nuclear membrane of normal brain neurons.
Mutations in SCA7 cause ataxin-7 accumulation in intranuclear inclusions, which can result in neuronal cell death.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.