Thermo Fisher Scientific ATXN7L3 Monoclonal Antibody (2ATX-2B1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Immunocytochemistry (ICC/IF)

1:100

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2ATX-2B1

Immunogen

Synthetic Peptide coupled to Ovalbumin corresponding to aa 278 to aa 296 of human ataxin 7L3 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ATXN7L3,uniProtId:Q14CW9-1,ncbiNodeId:9606,antigenRange:278-296,antigenLength:347,antigenImageFileName:MA3-084_ATXN7L3_Q14CW9-1_House_mouse.svg,antigenImageFileNamePDP:MA3-084_ATXN7L3_Q14CW9-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2633329

Product Specific Information

MA3-084 detects Ataxin 7L3 from human and mouse samples.

MA3-084 has been successfully used in Western blot, immunofluorescence, and ELISA applications.

Target Information

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.