Thermo Fisher Scientific ATXN7L3 Monoclonal Antibody (2ATX-2B1)

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

MA3-084 detects Ataxin 7L3 from human and mouse samples.
MA3-084 has been successfully used in Western blot, immunofluorescence, and ELISA applications.

Target Information

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination.
Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B.
The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription.
Required for nuclear receptor-mediated transactivation.
Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.
Regulates H2B monoubiquitination (H2Bub1) levels and affects subcellular distribution of ENY2, USP22, and ATXN7L3B.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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