Thermo Fisher Scientific SUV420H2 Recombinant Human Monoclonal Antibody (RAB-C409)

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-dependent

-

ChIP assay (ChIP)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Human / F(ab), kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

RAB-C409

Immunogen

This antibody was obtained by recombinant antibody (rAb) phage display recognizing SUV420H2 protein under non-denaturing conditions.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Metal-chelate chromatography

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

This antibody recognizes KMT5C (Histone-lysine N-methyltransferase KMT5C). It binds to a folded domain, amino acids 2-248. KMT5C is a histone methyltransferase that regulates transcription and maintenance of genome integrity.

Target Information

SUV420H2 is a histone methyltransferase that specifically trimethylates Lys-20 of histone H4. H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.