Thermo Fisher Scientific TIGIT Recombinant Armenian Hamster Monoclonal Antibody (4D4)
TIGIT 단백질을 특이적으로 인식하는 아르메니아 햄스터 유래 재조합 단클론 항체입니다. Flow cytometry 및 기능적 분석에 적합하며, 고순도의 Protein A 정제 항체입니다. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Functional Assay (Functional)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Armenian hamster / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4D4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Immunogen
Armenian hamsters were immunized with recombinant mouse TIGIT tetramers. Draining lymph nodes were fused with Sp2/0-Ag14 cells, selected in HAT (hypoxanthine/aminopterin/thymidine) medium, and supernatants were screened for specificity by ELISA and flow cytometry using TIGIT-transfectants.
Antigen Information:
- Target Family: TIGIT
- UniProt ID: P86176-1
- NCBI Node ID: 10090
- Antigen Range: 1–249
- Antigen Length: 249
Product Specific Information
4D4 specifically recognises TIGIT.
Target Information
Binds with high affinity to the poliovirus receptor (PVR), which causes increased secretion of IL10 and decreased secretion of IL12B, and suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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