Thermo Fisher Scientific SETD7 Recombinant Human Monoclonal Antibody (RAB-C220)
SETD7 단백질을 인식하는 인간 유래 재조합 단클론 항체로, ICC, Flow, ELISA, IP, ChIP 등 다양한 분석에 사용 가능. HEK293 세포에서 발현되며, 금속 킬레이트 크로마토그래피로 정제됨. 히스톤 H3 Lys-4 단메틸화 인식 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / F(ab), kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C220 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing SETD7 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes SETD7 (Histone-lysine N-methyltransferase SETD7). It binds to a folded domain comprising amino acids 2–366.
SETD7 is a histone methyltransferase that specifically monomethylates Lys-4 of histone H3, serving as an epigenetic transcriptional activation marker.
It plays a central role in activating transcription of genes such as collagenase and insulin.
Target Information
SETD7 is a histone methyltransferase that monomethylates Lys-4 of histone H3, marking regions for transcriptional activation.
It is recruited by IPF1/PDX-1 to the insulin promoter, activating transcription.
SETD7 also methylates non-histone proteins such as p53/TP53, TAF10, and possibly TAF7, recognizing the [KR]-[STA]-K motif.
Monomethylation of Lys-189 in TAF10 increases its affinity for RNA polymerase II, while monomethylation of Lys-372 in p53/TP53 stabilizes the protein and enhances transcriptional activation.
(Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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