Thermo Fisher Scientific SUV420H2 Recombinant Human Monoclonal Antibody (RAB-C409)
SUV420H2 단백질을 인식하는 인간 유래 재조합 단클론 항체로 ELISA 및 ChIP assay에 사용 가능. KMT5C 단백질의 접힌 도메인(aa 2-248)에 결합하며, 히스톤 H4 Lys-20 삼메틸화 연구에 적합. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C 단기 보관 권장.
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
ChIP assay (ChIP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Human / F(ab), kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C409 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing SUV420H2 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes KMT5C (Histone-lysine N-methyltransferase KMT5C). It binds to a folded domain (amino acids 2–248). KMT5C is a histone methyltransferase that regulates transcription and maintenance of genome integrity.
Target Information
SUV420H2 is a histone methyltransferase that specifically trimethylates Lys-20 of histone H4.
H4 Lys-20 trimethylation represents a specific tag for epigenetic transcriptional repression.
The protein mainly functions in pericentric heterochromatin regions, playing a central role in the establishment of constitutive heterochromatin.
SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1, and RBL2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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