Thermo Fisher Scientific Noggin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues P(156) V L Y A W N D L G S R F W P(170) of the human Noggin (NOG) protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Noggin,uniProtId:Q13253-1,ncbiNodeId:9606,antigenRange:156-170,antigenLength:232,antigenImageFileName:PA1-4521_Noggin_Q13253-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4521_Noggin_Q13253-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2151684

Product Specific Information

PA1-4521 detects Noggin (NOG) in human samples. The immunizing peptide sequence is 100% conserved in rat and mouse.

PA1-4521 has been successfully used in Western blot procedures. This antibody is specific for the ~32 kDa protein representing Noggin (NOG) .

PA1-4521 immunogen is a synthetic peptide corresponding to residues 156-170 of the human Noggin (NOG) protein.

Target Information

Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.