Thermo Fisher Scientific Nurr1 Polyclonal Antibody
Thermo Fisher Scientific의 Nurr1 Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 Nurr1 단백질을 검출합니다. Western blot 및 Immunohistochemistry에 적합하며, 고순도 Affinity chromatography 정제 제품입니다. 뇌 도파민 시스템 연구 및 신경학적 질환 관련 연구용으로 이상적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to an internal sequence (CTERHGLKEPKRVEE) of human Nurr1 protein (aa 513–526) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2267349 |
Product Specific Information
PA1-4519 detects Nurr1 in human, rat, and mouse samples.
It has been successfully used in Western blot and Immunohistochemistry procedures.
This antibody is specific for the ~70 kDa protein representing Nurr1.
The immunogen is a synthetic peptide corresponding to an internal sequence (CTERHGLKEPKRVEE) of human Nurr1 protein.
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene in humans.
Nurr1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression.
Misregulation of this gene may be associated with rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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