Thermo Fisher Scientific alpha-2c Adrenergic Receptor Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-4518 detects alpha-2c AR in human, rat, and mouse samples.
It has been successfully used in Western blot and Immunohistochemistry procedures.
The immunogen is a synthetic peptide corresponding to internal residues of the alpha-2c Adrenergic Receptor.
Store at 4°C for up to 3 months or at -20°C for longer periods. Avoid repeated freeze-thaw cycles.

Target Information

Alpha-2-adrenergic receptors belong to the G protein-coupled receptor superfamily and include three highly homologous subtypes: alpha2A, alpha2B, and alpha2C.
These receptors regulate neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
Mouse studies show that both alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release.
The alpha2A subtype inhibits transmitter release at high stimulation frequencies, while the alpha2C subtype modulates neurotransmission at lower nerve activity levels.
This gene encodes the alpha2C subtype, which lacks introns in both coding and untranslated sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.