Thermo Fisher Scientific Parkin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250-1:1,000

-

Immunoprecipitation (IP)

1:250-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Internal sequence of the 52 kDa Parkin human protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1077464

Product Specific Information

PA1-4552 detects Parkin in human samples.

PA1-4552 has been successfully used in Western blotting and immunoprecipitation procedures. By Western blot, this antibody detects a ~52 kDa protein representing Parkin in HEK cells stably expressing the protein.

PA1-4552 immunizing peptide corresponds to an internal sequence of the 52 kDa Parkin human protein.

Maintain antibody at 4ºC for up to 3 months. For long term storage, store at -20ºC, avoiding freeze/thaw cycles.

Target Information

The precise function of Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.