Thermo Fisher Scientific Ataxin 1 Monoclonal Antibody (N65/37), APC
Ataxin 1 단백질을 인식하는 마우스 단클론 항체로, APC 형광 표지되어 있습니다. Western blot 및 면역세포염색에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 단백질 G로 정제되었으며, 보존제가 포함되지 않습니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N65/37 |
| Immunogen | Synthetic peptide amino acids 746–761 (RKRRWSAPETRKLEKS) of mouse ataxin-1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932159 |
Additional Formats
- Unconjugated (MA5-27667)
- FITC (MA5-45706)
- PE (MA5-45708)
- PerCP (MA5-45707)
- Custom conjugation available upon request
Product Specific Information
- Rat: 93% identity (15/16 amino acids identical)
- Human: 87% identity (14/16 amino acids identical)
- 1 µg/mL of MA5-45705 detects Ataxin 1 in 20 µg of COS cells transfected with Ataxin-1 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 85 kDa.
- No cross-reactivity against phospho S751-Ataxin-1.
- Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence; negative by immunoblot.
- Formerly sold as clone S65-37.
Target Information
Autosomal dominant cerebellar ataxias (ADCA) are neurodegenerative disorders involving progressive degeneration of the cerebellum, brain stem, and spinal cord.
ADCA is divided into three groups (types I–III). ADCAI is genetically heterogeneous, including spinocerebellar ataxia (SCA) types 1, 2, 3, 4, and 6.
ADCAII (SCA7) presents with retinal degeneration, while ADCAIII (SCA5) is a pure cerebellar syndrome.
These diseases are caused by CAG repeat expansions in coding regions of SCA genes, producing elongated polyglutamine tracts.
The Ataxin 1 locus is mapped to chromosome 6, with diseased alleles containing 41–81 CAG repeats (normal: 6–39), associated with spinocerebellar ataxia type 1 (SCA1).
At least two transcript variants encode the same Ataxin 1 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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