Thermo Fisher Scientific Ataxin 1 Monoclonal Antibody (N65/37), PE
Ataxin 1 단백질을 검출하기 위한 Thermo Fisher Scientific의 단클론 항체로, PE 형광 접합 형태입니다. 인간, 생쥐, 랫트 반응성이 있으며 Western blot과 면역세포염색에 적합합니다. 높은 특이성과 낮은 교차 반응성을 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N65/37 |
| Immunogen | Synthetic peptide amino acids 746–761 (RKRRWSAPETRKLEKS) of mouse ataxin-1 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932162 |
Additional Formats
Product Specific Information
- Rat: 93% identity (15/16 amino acids identical)
- Human: 87% identity (14/16 amino acids identical)
- 1 µg/mL of MA5-45708 detects Ataxin 1 in 20 µg of COS cells transiently transfected with Ataxin-1 lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody.
- Detects approximately 85 kDa.
- No cross-reactivity against phosphor S751-Ataxin-1.
- Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence; negative by immunoblot.
- Formerly sold as clone S65-37.
Target Information
Autosomal dominant cerebellar ataxias (ADCA) are neurodegenerative disorders involving progressive degeneration of the cerebellum, brain stem, and spinal cord.
ADCA types I–III are classified by clinical features and genetic loci, including spinocerebellar ataxia (SCA) 1, 2, 3, 4, and 6.
ADCA is caused by CAG repeat expansion in the coding region, resulting in elongated polyglutamine tracts.
The Ataxin 1 gene is mapped to chromosome 6, with diseased alleles containing 41–81 CAG repeats (normal: 6–39), associated with SCA1.
At least two transcript variants encode the same protein.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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