Thermo Fisher Scientific Ataxin 1 Monoclonal Antibody (N65/37), PerCP

Thermo Fisher Scientific Ataxin 1 Monoclonal Antibody (N65/37), PerCP

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

• Rat: 93% identity (15/16 amino acids identical)
• Human: 87% identity (14/16 amino acids identical)
• 1 µg/mL of MA5-45707 detects Ataxin 1 in 20 µg of COS cells transiently transfected with Ataxin-1 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as secondary antibody.
• Detects approximately 85 kDa.
• No cross-reactivity against phospho S751-Ataxin-1.
• Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence; negative by immunoblot.
• Formerly sold as clone S65-37.

Target Information

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. ADCA types I–III have been identified, with genetic loci for spinocerebellar ataxia (SCA) 1, 2, 3, 4, and 6 assigned to distinct chromosomes.
ADCAII typically presents with retinal degeneration (SCA7), while ADCAIII (SCA5) is a pure cerebellar syndrome. Several SCA genes contain CAG repeats, and disease results from expansion of these repeats, leading to elongated polyglutamine tracts.
The Ataxin 1 gene is located on chromosome 6, with diseased alleles containing 41–81 CAG repeats compared to 6–39 in normal alleles, associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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