Thermo Fisher Scientific Huntington Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.

This antibody is specific towards HTT. A BLAST analysis was used to suggest cross-reactivity with Human, Mouse, and Rat based on 100% sequence homology. Cross-reactivity with HTT from other sources has not been determined.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product.

HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years. The huntingtin locus spans 180 kb and consists of 67 exons. The huntingtin gene is widely expressed and required for normal development. It is expressed as two alternatively polyadenylated forms with different abundance in fetal and adult tissues. The larger transcript (~13.7 kb) is predominant in brain tissue, while the smaller (~10.3 kb) is more widely expressed. The genetic defect may alter mRNA or protein function rather than eliminate transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.