Thermo Fisher Scientific Phospho-HDAC5 (Ser661) Polyclonal Antibody
HDAC5 단백질의 Ser661 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ELISA 등 다양한 응용 가능. 고순도 친화 크로마토그래피 정제, 무보존액, -20°C 저장 안정성 우수. 연구용으로 사용.
- 카탈로그번호
- 600-401-J21
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-HDAC5 (Ser661) Polyclonal Antibody
Thermo Fisher Scientific Phospho-HDAC5 (Ser661) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| ELISA | 1:20,000–1:60,000 |
| Immunoprecipitation (IP) | 0.2 µg/mL |
| Dot Blot (DB) | 1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the internal region surrounding phosphoserine 661 of human HDAC5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.12 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 50% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
This antibody is specific towards HDAC5. BLAST analysis suggests cross-reactivity with human HDAC5 based on 100% sequence homology. Cross-reactivity with HDAC5 from other sources has not been determined.
Target Information
Histones are key regulators of transcription, cell cycle progression, and development. Histone acetylation/deacetylation modifies chromatin structure and influences transcription factor access to DNA. HDAC5 belongs to the class II histone deacetylase family, possessing deacetylase activity and repressing transcription when tethered to a promoter. It coimmunoprecipitates with HDAC3 and interacts with myocyte enhancer factor-2 (MEF2) proteins, repressing MEF2-dependent genes. HDAC5 is associated with colon cancer, and two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.