Thermo Fisher Scientific HDAC7 (N-terminus) Polyclonal Antibody
HDAC7 N-말단을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA, IP에 사용 가능. 인간, 마우스, 랫드, 영장류 반응성. 고순도 Affinity chromatography 정제. 장기 보관 시 -20°C에서 안정적.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| ELISA | 1:20,000–1:60,000 |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | HDAC7 affinity purified antibody prepared from whole rabbit serum immunized with a synthetic peptide corresponding to the N-terminal region of human HDAC7. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.16 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific towards HDAC7. BLAST analysis suggests cross-reactivity with Human, Mouse, Rat, and Primate based on 100% sequence homology. Cross-reactivity with HDAC7 from other sources has not been determined.
Target Information
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of core histones (H2A, H2B, H3, and H4).
Histone deacetylation serves as an epigenetic repression tag and plays a key role in transcriptional regulation, cell cycle progression, and developmental events.
HDACs act via formation of large multiprotein complexes. HDAC4 is involved in muscle maturation through interaction with MEF2A, MEF2C, and MEF2D, and in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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