Thermo Fisher Scientific Huntington Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• This antibody is specific towards HTT.
• BLAST analysis suggests cross-reactivity with Human, Mouse, and Rat based on 100% sequence homology.
• Cross-reactivity with HTT from other sources has not been determined.

Target Information

Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years.

The huntingtin locus spans 180 kb and consists of 67 exons. The gene is widely expressed and required for normal development. It is expressed as two alternatively polyadenylated forms showing different abundance in fetal and adult tissues.

• Larger transcript: ~13.7 kb, predominantly in adult and fetal brain
• Smaller transcript: ~10.3 kb, more widely expressed

The genetic defect leading to Huntington’s disease may not eliminate transcription but may alter mRNA properties or protein function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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