Thermo Fisher Scientific Huntington Polyclonal Antibody
Huntington 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ELISA, IP 등에 사용 가능. Human, Mouse, Rat 반응성. Rabbit IgG 기반, 액상 형태로 -20°C 보관 권장. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| ELISA | 1:20,000–1:60,000 |
| Immunoprecipitation (IP) | 0.1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Huntington affinity purified antibody prepared from whole rabbit serum immunized with a synthetic peptide corresponding to the C-terminus of human Huntington disease protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 30% glycerol, 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as an undiluted liquid.
- Dilute only prior to immediate use.
- This antibody is specific towards HTT.
- BLAST analysis suggests cross-reactivity with Human, Mouse, and Rat based on 100% sequence homology.
- Cross-reactivity with HTT from other sources has not been determined.
Target Information
Huntingtin is a disease gene linked to Huntington’s disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, translating as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10–20 years.
The huntingtin locus spans 180 kb and consists of 67 exons. The gene is widely expressed and required for normal development. It is expressed as two alternatively polyadenylated forms showing different abundance in fetal and adult tissues.
- Larger transcript: ~13.7 kb, predominantly in adult and fetal brain
- Smaller transcript: ~10.3 kb, more widely expressed
The genetic defect leading to Huntington’s disease may not eliminate transcription but may alter mRNA properties or protein function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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