Thermo Fisher Scientific Coagulation Factor VIII (Cleaved form, N-term) Polyclonal Antibody
인간 Coagulation Factor VIII(N-terminal, cleaved form)을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS buffer에 안정화제 포함. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 0.1–1 µg/mL
- Immunohistochemistry (Paraffin) (IHC (P)): 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to N-terminal cleavage form (VLLKRHHQR) of human FVIII protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human colon carcinoma
- Cellular location: Secreted, extracellular space
Target Information
Coagulation factor VIII participates in the intrinsic pathway of blood coagulation. It acts as a cofactor for factor IXa, facilitating conversion of factor X to activated factor Xa in the presence of Ca²⁺ and phospholipids.
This gene produces two alternatively spliced transcripts:
- Transcript variant 1 encodes a large glycoprotein (isoform a) that circulates in plasma and associates with von Willebrand factor.
- Transcript variant 2 encodes a smaller protein (isoform b) containing the phospholipid-binding domain essential for coagulant activity.
Defects in this gene cause Hemophilia A, a recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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