Thermo Fisher Scientific Phospho-Catenin-beta (Ser33) Polyclonal Antibody
β-Catenin의 Ser33 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Rat에 반응. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. 세포 내 위치 분석 및 Wnt 신호전달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the epitope SGIHS with a single phosphorylation site Ser33 of human β-catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 25 mM Tris with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human lung adenocarcinoma
- Cellular location: Cytoplasm, Nucleus
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signal transduction. It interacts with the cytoplasmic domain of E-cadherin, linking it to alpha-catenin and the actin cytoskeleton. Beta-catenin also associates with complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as Wnt/Wingless.
This protein plays a key role in morphogenesis and is expressed in various hair follicle cells, basal and matrix cells, and epithelial tissues. Dysregulation of beta-catenin is implicated in multiple cancers, including pilomatrixoma, medulloblastoma, colorectal, ovarian, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting transcription of genes such as cyclin D and c-myc, which drive cell proliferation and tumorigenesis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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