Thermo Fisher Scientific Coagulation Factor VIII (Fused form) Polyclonal Antibody
인체 Coagulation Factor VIII에 특이적인 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공. 연구용으로만 사용 가능하며, 혈액 응고 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to fused portion of human FVIII protein surrounding HQREI domain, with depletion of cleavage terminus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Human colon carcinoma
- Cellular location: Secreted, extracellular space
Target Information
Coagulation Factor VIII participates in the intrinsic pathway of blood coagulation. It acts as a cofactor for Factor IXa, which, in the presence of Ca²⁺ and phospholipids, converts Factor X to its activated form Xa.
This gene produces two alternatively spliced transcripts:
- Transcript variant 1 encodes a large glycoprotein (isoform a) that circulates in plasma and associates with von Willebrand factor.
- Transcript variant 2 encodes a smaller protein (isoform b) consisting primarily of the phospholipid-binding domain essential for coagulant activity.
Defects in this gene result in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송 정보
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