Thermo Fisher Scientific SCNN1B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: SCNN1B.

Target Information

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium and water through the apical membrane of epithelial cells. Regulates sodium reabsorption in kidney, colon, lung, and sweat glands, and contributes to taste perception.

The channel is a heterotetramer composed of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.

Defects in SCNN1B are associated with:

• Autosomal recessive pseudohypoaldosteronism type 1 (PHA1): A rare salt-wasting disease characterized by neonatal dehydration, hyponatremia, hyperkalemia, metabolic acidosis, and weight loss.
• Liddle syndrome: An autosomal dominant disorder leading to pseudoaldosteronism and hypertension with hypokalemic alkalosis due to constitutive activation of the renal epithelial sodium channel.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.