Thermo Fisher Scientific SCNN1B Polyclonal Antibody
SCNN1B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western Blot 및 IHC에 적합합니다. 합성 펩타이드를 면역원으로 사용하며, 사람 시료에 반응합니다. 동결건조 형태로 제공되며 장기 보관 시 -20°C 보관을 권장합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 570–640 of human SCNN1B conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: SCNN1B.
Target Information
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates electrodiffusion of luminal sodium and water through the apical membrane of epithelial cells. Regulates sodium reabsorption in kidney, colon, lung, and sweat glands, and contributes to taste perception.
The channel is a heterotetramer composed of two alpha, one beta, and one gamma subunit; a delta subunit can replace the alpha subunit. Interacts with WW domains of NEDD4, NEDD4L, WWP1, and WWP2.
Defects in SCNN1B are associated with:
- Autosomal recessive pseudohypoaldosteronism type 1 (PHA1): A rare salt-wasting disease characterized by neonatal dehydration, hyponatremia, hyperkalemia, metabolic acidosis, and weight loss.
- Liddle syndrome: An autosomal dominant disorder leading to pseudoaldosteronism and hypertension with hypokalemic alkalosis due to constitutive activation of the renal epithelial sodium channel.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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