Thermo Fisher Scientific SCNN1A Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000
• Publications: View 1 publication

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: SCNN1A.

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarity, possessing two short intracellular amino and carboxyl termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (α, β, γ). ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron, thus regulating blood pressure. ENaC function is partly regulated through association with the CFTR chloride channel.
Gain-of-function mutations in β- or γ-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in α- or β-ENaC cause pseudohypoaldosteronism type I (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.