Thermo Fisher Scientific PSD93 Recombinant Rabbit Monoclonal Antibody (7H7L3)

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Rat, Mouse, Monkey, and Chicken.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

PSD-93 (chapsyn-110) is a plasma membrane-associated protein found in synaptic junctions. It is uniquely expressed in Purkinje neuron cell bodies and dendrites. PSD-93 contains three PDZ domains (~90 amino acids each), one SH3 domain, and a carboxyl-terminal Guanylate Kinase homology (GuK) domain that is enzymatically inactive.

PDZ-domain interactions are thought to play roles in receptor and channel clustering, contributing to neuronal plasticity. PSD-93 participates in clustering of NMDA receptors and shaker-type potassium channels at the synaptic membrane. These proteins share a C-terminal T/SXV motif enabling PDZ-domain binding. Additionally, neuronal nitric oxide synthase (nNOS), which lacks this motif but has its own PDZ domain, associates with PSD-93 via pseudo-homotypic PDZ–PDZ interaction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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