Thermo Fisher Scientific GLI2 Recombinant Rabbit Monoclonal Antibody (9H25L4)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 5 µg/mL

ChIP assay (ChIP)

• Tested Dilution: 2.5 µg/1x10^6 cells

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Bovine, and Rabbit.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The DNA sequences encoding immunoreactive rabbit antibodies are cloned and screened to select optimal production candidates.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Gli-2 belongs to the C2H2-type zinc finger protein subclass of the Gli family. These transcription factors bind DNA through conserved zinc finger motifs and mediate Sonic hedgehog (Shh) signaling.
Gli proteins are implicated as oncogenes in embryonal carcinoma cells and play roles in embryogenesis.
The encoded protein localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression.
Associated phenotypes include:

• Greig cephalopolysyndactyly syndrome
• Pallister-Hall syndrome
• Preaxial polydactyly type IV
• Postaxial polydactyly types A1 and B

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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