Thermo Fisher Scientific ABCC7 (CFTR) Polyclonal Antibody
Rabbit polyclonal antibody targeting human CFTR (ABCC7) protein. Validated for WB and IHC with high specificity. Lyophilized form for flexible storage. Suitable for cystic fibrosis research applications.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 1150–1200 of human ABCC7 (CFTR), conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4 °C for short term. For long term storage, store at −20 °C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: CFTR.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations in the CFTR gene, which encodes a cAMP-regulated chloride channel. Approximately 70% of CF cases involve a deletion of phenylalanine at position 508 (ΔF508), leading to abnormal chloride transport. This mutation often results in lung and liver disease. Interestingly, CFTR also serves as an entry point for Salmonella typhi in intestinal epithelial cells, and ΔF508 heterozygote/homozygote mice show significant reductions in bacterial uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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