Thermo Fisher Scientific CLCN7 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CLCN7, reactive with human, mouse, and rat. Suitable for WB and IHC applications. Lyophilized form with no preservative, ideal for research use. Stable at -20°C with glycerol addition.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 250–300 of human CLCN7 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
- Specificity: CLCN7.
Target Information
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and intracellular organelles. This gene encodes chloride channel 7. Defects in this gene cause osteopetrosis autosomal recessive type 4 (OPTB4), also known as infantile malignant osteopetrosis type 2, and autosomal dominant osteopetrosis type 2 (OPTA2), also known as Albers-Schonberg disease or marble disease. Osteopetrosis is a rare genetic disorder characterized by abnormally dense bone due to defective resorption of immature bone. OPTA2 is the most common form, occurring in adolescence or adulthood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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