Thermo Fisher Scientific CLCN1 Polyclonal Antibody
Rabbit polyclonal antibody against human CLCN1, validated for WB and IHC. Recognizes N-terminal region of Chloride channel protein 1. Lyophilized form, reconstitutable in sterile water. Suitable for research use in muscle and nerve ion channel studies.
- 카탈로그번호
- OSC00145W-100UL
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CLCN1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human Chloride channel protein 1 (CLCN1) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CLCN1.
Target Information
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, essential for all living cells.
CLCs influence excitability in muscle and nerve cells, assist in organic solute transport, and maintain cellular volume.
CLCN1 is highly expressed in skeletal muscle, and mutations in CLCN1 cause myotonia, a disorder characterized by muscle stiffness and renal salt wasting.
CLCN2 is found in epithelial tissues and may be a therapeutic target for cystic fibrosis.
CLCN3 is abundant in neuronal tissue, while CLCN4 is expressed in skeletal and cardiac muscle as well as brain.
Mutations in CLCN5 cause Dent’s disease, and CLCN6/7 are broadly expressed in testis, kidney, brain, and muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.