Thermo Fisher Scientific CD47 Monoclonal Antibody (B6H12), Alexa Fluor 488, eBioscience

Thermo Fisher Scientific CD47 Monoclonal Antibody (B6H12), Alexa Fluor 488, eBioscience

Applications and Tested Dilution

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• eFluor 450
• FITC
• Functional Grade
• NovaFluor Blue 660-120S
• NovaFluor Red 700
• NovaFluor Red 725
• NovaFluor Red 755
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• PE-Cyanine5
• PE-Cyanine7
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

The monoclonal antibody B6H12 reacts to CD47, also known as integrin-associated protein (IAP) and neurophilin.
CD47 is a glycosylated five-transmembrane protein involved in adhesion through interactions with SIRP and integrins (CD51/CD61, CD41/CD61).
It mediates bidirectional signaling, regulates macrophage phagocytosis, and acts as a receptor for thrombospondin.

• CD47 expression is found in most hematopoietic cells (T cells, B cells, monocytes, platelets, erythrocytes) and also in non-hematopoietic cells.
• This antibody has neutralizing activity.
• Reported for flow cytometric analysis of normal human peripheral blood cells.
• Tested at 5 µL (1.0 µg)/test, suitable for a final volume of 100 µL per sample.
• Excitation: 488 nm, Emission: 519 nm, Laser: Blue Laser.

Target Information

CD47 (Integrin-associated protein, IAP) is a ubiquitously expressed transmembrane glycoprotein that interacts with integrins and regulates signaling pathways such as G protein activation.
It functions in calcium signaling upon cell adhesion, serves as a receptor for thrombospondin, and participates in membrane transport and signal transduction.
CD47 binds CD172a (SIRPα) on macrophages, inhibiting phagocytosis of CD47-positive cells.
It plays roles in cell migration, B cell adhesion, T cell activation, chondrocyte mechanotransduction, and neuronal development, especially in synapse-rich brain and retina regions.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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