Thermo Fisher Scientific Phospho-ROR2 (Ser449) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Product Specifications

Product Specific Information

Antibody detects endogenous levels of ROR2 only when phosphorylated at Ser449.

Target Information

ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. It plays a role in early chondrocyte formation, cartilage and growth plate development.
This protein is highly expressed during early embryonic development but decreases significantly after day 16, with very low levels in adult tissues.

Defects in ROR2 cause:

• Brachydactyly type B1 (BDB1): Autosomal dominant skeletal disorder with hypoplasia/aplasia of distal phalanges and nails.
• Robinow syndrome (RRS): Autosomal recessive disorder characterized by skeletal dysplasia, limb bone shortening, spinal defects, brachydactyly, and facial dysmorphism.

The protein contains:

• 1 frizzled (FZ) domain
• 1 immunoglobulin-like C2-type domain
• 1 kringle domain

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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