Thermo Fisher Scientific Phospho-MER/TYRO3 (Tyr753, Tyr685) Polyclonal Antibody
Phospho-MER/TYRO3 (Tyr753, Tyr685) 폴리클로날 항체로 인산화된 MER/TYRO3 단백질을 특이적으로 검출. Western blot 및 ICC/IF에 적합. 인간, 생쥐, 랫트 반응성. 고순도 정제 및 안정적인 PBS/glycerol 저장.
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- PA5106145
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MERTK (Accession Q12866), corresponding to amino acid residues around phosphorylated Tyr753 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817543 |
Product Specific Information
Antibody detects endogenous levels of MER/TYRO3 only when phosphorylated at Tyr753/Tyr685.
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. It regulates cell survival, migration, differentiation, and efferocytosis. Ligand binding induces autophosphorylation, creating docking sites for signaling molecules such as GRB2 or PLCG2, leading to phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK signaling contributes to macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and inhibition of Toll-like receptor-mediated innate immune response through STAT1 activation and SOCS1/3 induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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