Thermo Fisher Scientific Phospho-Met (Tyr1313) Polyclonal Antibody
c-Met 단백질의 Tyr1313 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 적합하며, 인간·마우스·랫트 시료에 반응. 1 mg/mL 농도의 액상 형태로 PBS/glycerol buffer에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MET (Accession P08581), corresponding to amino acid residues around phosphorylated Tyr1313. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817544 |
Product Specific Information
This antibody detects endogenous levels of c-Met only when phosphorylated at Tyr1313.
Target Information
MET (c-Met) is a receptor-like tyrosine kinase whose dysregulation has been linked to various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development processes including gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling.
Aberrant MET signaling has been implicated in cancers such as gastric, renal, and breast, making it an important target for cancer therapeutics and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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