Thermo Fisher Scientific Phospho-MYPT1 (Ser507) Polyclonal Antibody
MYPT1 단백질의 Ser507 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에서 검증됨. Human, Mouse, Rat 시료에 반응. PBS/glycerol buffer에 보관되며, -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications and Tested Dilution
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PPP1R12A (Accession O14974), corresponding to amino acid residues around phosphorylated Ser507. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817546 |
Product Specific Information
This antibody detects endogenous levels of MYPT1 only when phosphorylated at Ser507.
Target Information
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is a regulatory subunit that controls actin–myosin interactions downstream of Rho GTPase signaling. RhoA-GTP activates Rho-kinase, which phosphorylates and inactivates MYPT1, leading to increased myosin light chain (MLC) phosphorylation and smooth muscle contraction. Overexpression of RhoA or its active form increases MBS and MLC phosphorylation. Multiple transcript variants encoding different isoforms exist for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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