Thermo Fisher Scientific CD59 Recombinant Rabbit Monoclonal Antibody (015)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

This antibody has specificity for Human CD59.

Target Information

CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC). It regulates complement activation by preventing the formation of the cytolytic pore in the plasma membrane. CD59 binds complement C8 and/or C9 during MAC assembly, inhibiting incorporation of multiple C9 copies required for pore formation.

CD59 also acts as a low-affinity ligand for human CD2, contributing to T cell costimulation and lymphocyte signal transduction. Mutations in this gene can cause CD59 deficiency, associated with hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.