Thermo Fisher Scientific CD59 Recombinant Rabbit Monoclonal Antibody (015)
인간 CD59 단백질을 인식하는 재조합 토끼 단클론 항체입니다. ELISA에 적합하며 높은 특이성과 일관된 로트 간 재현성을 제공합니다. 방부제가 포함되지 않아 필요 시 sodium azide를 첨가할 수 있습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- ELISA (ELISA): 1:250–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 015 |
| Immunogen | Recombinant Human CD59 Protein (Met1–Glu101) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785951 |
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
This antibody has specificity for Human CD59.
Target Information
CD59 (Protectin) is a small (18–20 kDa) GPI-anchored, ubiquitously expressed inhibitor of the membrane attack complex (MAC). It regulates complement activation by preventing the formation of the cytolytic pore in the plasma membrane. CD59 binds complement C8 and/or C9 during MAC assembly, inhibiting incorporation of multiple C9 copies required for pore formation.
CD59 also acts as a low-affinity ligand for human CD2, contributing to T cell costimulation and lymphocyte signal transduction. Mutations in this gene can cause CD59 deficiency, associated with hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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