Thermo Fisher Scientific CD69 Recombinant Rabbit Monoclonal Antibody (006)

Applications

• ELISA (ELISA): 1:250–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody has specificity for Human CD69/CLEC2C.

Target Information

CD69 (AIM, Active Inducer Molecule) is a gp28/34 disulfide-bonded homodimer (~60 kDa under non-reducing conditions). It contains one or two N-linked oligosaccharides and is present on activated platelets.
In normal peripheral blood, a variable percentage of cells express CD69 antigen, which is involved in lymphocyte signal transduction. Expression of CD69 is induced upon T lymphocyte activation and may play a role in proliferation. The protein may also transmit signals in natural killer cells and platelets.
Alternative splicing results in multiple transcript variants of CD69.
Diseases associated with CD69 dysfunction include coccidiodomycosis and asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.