Thermo Fisher Scientific KCNQ4 Monoclonal Antibody (N43/6), PE
KCNQ4 단백질을 검출하기 위한 PE-conjugated mouse monoclonal antibody. Western blot, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein G 정제, 1 mg/mL 농도. 4°C 보관, 보존제 없음.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N43/6 |
| Immunogen | Fusion protein amino acids 2–77 of human KCNQ4 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931868 |
Available Formats
- Unconjugated (MA5-27653)
- APC (MA5-45411)
- FITC (MA5-45412)
- PerCP (MA5-45413)
- Request custom conjugation
Product Specific Information
1 µg/mL of MA5-45414 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 77 kDa.
Target Information
The protein encoded by this gene forms a potassium channel that regulates neuronal excitability, particularly in sensory cells of the cochlea. The channel current is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, an anti-convulsant drug. The encoded protein can form homomultimeric or heteromultimeric channels with KCNQ3. Defects in this gene cause nonsyndromic sensorineural deafness type 2, an autosomal dominant progressive hearing loss. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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