Thermo Fisher Scientific KCNQ4 Monoclonal Antibody (N43/6), FITC
KCNQ4 단백질을 인식하는 FITC 결합 마우스 단클론 항체로, 인간·마우스·랫트 시료에 반응합니다. WB, IHC, ICC 등 다양한 응용에 적합하며, 498/517 nm 형광 특성을 가집니다. 단백질 G 정제, 보존제 없음, 4°C 암소 보관.
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Thermo Fisher Scientific KCNQ4 Monoclonal Antibody (N43/6), FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N43/6 |
| Immunogen | Fusion protein amino acids 2–77 of human KCNQ4 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS (pH 7.4) with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931866 |
Available Formats
- Unconjugated (MA5-27653)
- APC (MA5-45411)
- PE (MA5-45414)
- PerCP (MA5-45413)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45412 was sufficient for detection of KCNQ4 in 10 µg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 77 kDa.
Target Information
The KCNQ4 gene encodes a potassium channel important for neuronal excitability, particularly in cochlear sensory cells. The channel’s current is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, an anti-convulsant drug. It can form homomultimeric or heteromultimeric channels with KCNQ3. Mutations in KCNQ4 cause nonsyndromic sensorineural deafness type 2, an autosomal dominant progressive hearing loss. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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