Thermo Fisher Scientific KCNQ1 Monoclonal Antibody (N37A/10), PE

Applications and Tested Dilutions

Product Specifications

Available Formats

• Unconjugated (MA5-27676)
• APC (MA5-45407)
• FITC (MA5-45408)
• PerCP (MA5-45409)
• Custom conjugation available upon request

Product Specific Information

1 µg/mL of MA5-45410 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 75 kDa.

Target Information

Voltage-gated K⁺ channels in the plasma membrane control repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells.
KCNQ1, together with KCNE1, forms a specific K⁺ channel predominantly expressed in the heart and cochlea, regulating the slow, depolarization-activated potassium current.
Mutations in KCNQ1 and KCNE1 genes can cause cardiac disease by impairing electrical signaling, while KCNQ4 mutations are linked to deafness. KCNQ proteins, including KCNQ1 and KCNQ4, have six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in tissues such as the cochlea, where it is found in outer hair cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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