Thermo Fisher Scientific KCNQ1 Monoclonal Antibody (N37A/10), PE
KCNQ1 단백질을 인식하는 마우스 단클론 항체로, PE 형광 표지되어 세포 분석 및 면역염색에 적합합니다. Human, Mouse, Rat, Hamster 반응성이 있으며, WB, IHC, ICC 등 다양한 응용에 사용 가능합니다. Protein G로 정제된 액상 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 | |
| Immunocytochemistry (ICC/IF) | 1:100 | |
| Immunoprecipitation (IP) | Assay-dependent | |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N37A/10 |
| Immunogen | Fusion protein amino acids 2–101 of human KCNQ1 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931864 |
Available Formats
- Unconjugated (MA5-27676)
- APC (MA5-45407)
- FITC (MA5-45408)
- PerCP (MA5-45409)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45410 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 75 kDa.
Target Information
Voltage-gated K⁺ channels in the plasma membrane control repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells.
KCNQ1, together with KCNE1, forms a specific K⁺ channel predominantly expressed in the heart and cochlea, regulating the slow, depolarization-activated potassium current.
Mutations in KCNQ1 and KCNE1 genes can cause cardiac disease by impairing electrical signaling, while KCNQ4 mutations are linked to deafness. KCNQ proteins, including KCNQ1 and KCNQ4, have six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in tissues such as the cochlea, where it is found in outer hair cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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