Thermo Fisher Scientific UFD1L Polyclonal Antibody
UFD1L 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 ELISA에 사용 가능하며, Human, Mouse, Rat에 반응합니다. 고순도 Affinity Chromatography로 정제되어 안정적인 결과를 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific UFD1L Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–307 of human UFD1L (NP_005650.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.42 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914610 |
Product Specific Information
Positive test controls include: MCF7, Jurkat, HeLa, A-431, Mouse brain, Mouse heart, Mouse skeletal muscle, Rat brain.
The target is usually found in the following locations: Cytoplasm, Nucleus, Cytosol.
Immunogen sequence:
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP ERQVQHEEST EGEADHSGYA GELGFRAFSG SGNRLDGKKK GVEPSPSPIK PGDIKRGIPN YEFKLGKITF IRNSRPLVKK VEEDEAGGRF VAFSGEGQSL RKKGRKP
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, potentiating their degradation by the 26S proteasome.
Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
The UFD1 protein, originally characterized in yeast S. cerevisiae, has a human homolog, UFD1L.
In vitro, UFD1 attenuates degradation of Ub-fusions with substitutions at the Gly76 moiety by selective multiubiquitination.
Mutations within the UFD1 gene are implicated in CATCH22 syndrome (cardiac defects, cleft palate, hypocalcemia), suggesting a link between this proteolytic pathway and developmental abnormalities.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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