Thermo Fisher Scientific TAGLN2 Polyclonal Antibody
TAGLN2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 적합. 인간 및 흰쥐 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 저장 가능. 연구용 전용.
- 카탈로그번호
- PA5121035
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–199 of human TAGLN2 (NP_003555.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.88 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2914607 |
Product Specific Information
- Positive test controls: HeLa, A-549, Mouse heart
- Immunogen sequence:
MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE NFQNWLKDGT VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT NRGASQAGMT GYGMPRQIL
Target Information
Transgelin (also designated SM22alpha) is expressed abundantly in smooth muscle cells. Transgelin-2 (also known as SM22alpha homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells.
The human transgelin-2 gene (TAGLN2), located on chromosome 1q23.1–q25, encodes a 199 amino acid protein containing a calponin-like repeat and a calponin-homology (CH) domain. Transgelin-2 may function similarly to transgelin.
During embryogenesis, transgelin is expressed in smooth, cardiac, and skeletal muscle, but later restricted to vascular and visceral smooth muscle cells. Transgelin is downregulated in several transformed cell lines, suggesting that reduced expression may indicate early transformation.
Transgelin binds actin, inducing actin fiber gelation within minutes, at a binding ratio of 1:6 actin monomers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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