Thermo Fisher Scientific ASGR1 Polyclonal Antibody
ASGR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC(P), ELISA에 사용 가능하며 고순도 Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–150 of human ASGR1 (NP_001662.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.43 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914613 |
Product Specific Information
- Positive test controls: HepG2, U-937, Mouse liver, Rat liver
- Localization: Membrane, Secreted, Single-pass type II membrane protein
Immunogen sequence:
MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL LLLVVVCVIG SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR KMKSLESQLE KQQKDLSEDH SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues. It is expressed on the surface of hepatocytes, localized to sinusoidal and lateral plasma membranes but not on the bile canalicular membrane.
The mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues. The rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3. The monoclonal antibody 8D7 recognizes an epitope of RHL-1 and cross-reacts with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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