Thermo Fisher Scientific TIN2 Polyclonal Antibody
TIN2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot과 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보존되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 202–451 of human TIN2/TINF2 (NP_001092744.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2914608 |
Product Specific Information
Positive test controls include:
- MCF7
- HepG2
- Mouse skeletal muscle
- Mouse heart
Subcellular localization: Chromosome, Nucleus, Nucleus matrix, Telomere
Immunogen sequence:
ECSVTDSVNL AEPMEQNPPQ QQRLALHNPL PKAKPGTHLP QGPSSRTHPE PLAGRHFNLA PLGRRRVQSQ WASTRGGHKE RPTVMLFPFR NLGSPTQVIS KPESKEEHAI YTADLAMGTR AASTGKSKSP CQTLGGRALK ENPVDLPATE QKENCLDCYM DPLRLSLLPP RARKPVCPPS LCSSVITIGD LVLDSDEEEN GQGEGKESLE NYQKTKFDTL IPTLCEYLPP SGHGAIPVSS CDCRDSSRPL
Target Information
TRF1 is a negative regulator of telomere length maintenance. Two proteins, tankyrase and TIN2, bind to mammalian TRF1.
Tankyrase, homologous to ankyrins and PARP catalytic domains, localizes to telomeres via TRF1 binding and exhibits PARP activity.
ADP-ribosylation of TRF1 reduces its telomeric DNA binding, suggesting telomere regulation by poly(ADP)-ribosylation.
TIN2 interacts with TRF1, localizes to telomeres, and is essential for telomere length regulation.
TIN2 and TRF1 are constitutively expressed, acting together to balance telomere elongation by telomerase.
However, endogenous expression is low, making visualization by immunostaining difficult in some cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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