Thermo Fisher Scientific Phospho-cGKII (Ser126) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PRKG2(Accession Q13237), corresponding to amino acid residues around phosphorylated Ser126. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:cGKII,uniProtId:Q13237-1,ncbiNodeId:9606,antigenRange:126,antigenLength:762,antigenImageFileName:PA5-105913_cGKII_Q13237-1_Rabbit.svg,antigenImageFileNamePDP:PA5-105913_cGKII_Q13237-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817312

Product Specific Information

Antibody detects endogenous levels of CGK2 only when phosphorylated at Ser126.

Target Information

PRKG2 (PKG2, cGKII) exhibits many cellular functions and has cAMP- and cGMP-dependent protein kinase activity. cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Identification of the pathway that mediates intestinal fluid secretion by E. coli. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.