Thermo Fisher Scientific PTEN Monoclonal Antibody (1B8)
PTEN 단백질을 검출하기 위한 Mouse monoclonal antibody(클론 1B8). Western blot, IHC, ICC, Flow cytometry, ELISA에 사용 가능. Human 및 Mouse 시료 반응성. 종양 억제 단백질 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B8 |
| Immunogen | Purified recombinant fragment of PTEN expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10976969 |
Product Specific Information
MA5-15560 targets PTEN in indirect ELISA, ICC, IF, FACS, and WB applications and shows reactivity with human and mouse samples.
The immunogen is a purified recombinant fragment of PTEN expressed in E. coli.
MA5-15560 detects PTEN, which has a predicted molecular weight of approximately 54 kDa.
Target Information
PTEN is a tumor suppressor frequently mutated in various cancers.
It encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase containing a tensin-like domain and a catalytic domain similar to dual-specificity protein tyrosine phosphatases.
Unlike most protein tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates.
PTEN negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate and functions as a tumor suppressor by inhibiting the AKT/PKB signaling pathway.
It modulates the AKT-mTOR pathway, influencing neuron integration, positioning, dendritic development, and synapse formation during adult neurogenesis.
PTEN may also regulate insulin signaling and glucose metabolism in adipose tissue.
The nuclear monoubiquitinated form has greater apoptotic potential, while the cytoplasmic nonubiquitinated form exhibits reduced tumor suppressive ability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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