Thermo Fisher Scientific CD183 (CXCR3) Monoclonal Antibody (CEW33D), PE-Cyanine7, eBioscience
인간 CD183(CXCR3)을 인식하는 단클론 항체로, PE-Cyanine7으로 결합되어 유세포분석(Flow Cytometry)에 최적화되었습니다. CEW33D 클론은 활성화된 T세포, NK세포 등에서 발현되는 CXCR3 검출에 사용되며, 광민감성이 있어 암실 보관이 필요합니다.
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Applications and Tested Dilution
- Application: Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.5 µg)/test
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-Cyanine7, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CEW33D |
| Conjugate | PE-Cyanine7 |
| Excitation/Emission Max | 569/780 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573418 |
Available Formats
- APC
- Biotin
- Brilliant UV 615
- eFluor 660
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Red 725
- NovaFluor Yellow 690
- PE
- PE-eFluor 610
- Request custom conjugation
Product Specific Information
The CEW33D monoclonal antibody reacts with human CD183 (CXCR3), a G protein-coupled chemokine receptor that binds CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC). CD183 is associated with type 1 immunity and is upregulated in Th1 cells, CD8 effector cells, NK, and NKT cells. It mediates infiltration of inflamed tissues and is also expressed on some B cells and plasmacytoid dendritic cells.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells. Use 5 µL (0.5 µg) per test (100 µL final volume). Cell count: 10⁵–10⁸ cells/test.
Light Sensitivity: Protect from light; tandem dye is photo-sensitive.
Fixation: Samples can be stored up to 3 days at 4°C in the dark using:
- IC Fixation Buffer (Product #00-8222-49)
- 1-step Fix/Lyse Solution (Product #00-5333-54)
Excitation: 488–561 nm
Emission: 775 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
This gene encodes a G protein-coupled receptor selective for chemokines IP10, Mig, and I-TAC. These ligands belong to the CXC chemokine subfamily. Binding induces leukocyte trafficking responses such as integrin activation, cytoskeletal changes, and chemotactic migration. The receptor couples with Gi proteins and undergoes phosphorylation-dependent internalization upon activation. It is expressed in effector/memory T cells and inflamed tissues, mediating recruitment of inflammatory cells. This receptor is a potential target for anti-inflammatory drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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