Thermo Fisher Scientific CD40 Chimeric Recombinant Mouse Monoclonal Antibody (1C10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody binds mouse CD40, a member of the tumor necrosis factor receptor superfamily. CD40 is an integral membrane protein expressed on the surface of B lymphocytes.

Target Information

The CD40 antigen is a single-chain glycoprotein belonging to the tumor necrosis factor/nerve growth factor superfamily and shows significant homology to the Hodgkin’s disease-associated antigen CD30.
CD40 is expressed on all B cells except plasma cells and is also found on some epithelial cells, carcinomas, and lymphoid dendritic cells.
It plays a crucial role in immune and inflammatory responses, including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
AT-hook transcription factor AKNA regulates CD40 expression, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 to mediate signal transduction.
The CD40-CD40L interaction is necessary for amyloid-beta-induced microglial activation, implicated in early Alzheimer’s disease pathogenesis.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Diseases associated with CD40 dysfunction include Type 3 Hyper-IgM immunodeficiency and CD40 ligand deficiency.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.