Thermo Fisher Scientific CD38 Chimeric Recombinant Rabbit Monoclonal Antibody (HB7)

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1 µg/mL

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody binds to an epitope between amino acids 273–285 of human CD38, an approximately 45 kDa type II transmembrane protein expressed on pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, NK cells, myeloblasts, and erythroblasts. CD38 expression is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone AT13/5 (Ab00289) (Ellis 1995).

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells. It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase or as a cell surface receptor.

Antibodies to CD38 are useful for:

• Subtyping lymphomas and leukemias
• Detection of plasma cells (e.g., identification of myelomas)
• Marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.