Thermo Fisher Scientific Pan Ras Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Positive Control: A549, H1299, HCT116, KRAS, HRAS, NRAS, zebrafish liver, zebrafish GI, whole zebrafish
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, characterized by prenatal overgrowth, postnatal growth deficiency, tumor predisposition, mental retardation, and distinctive facial and cardiovascular abnormalities. Defects in this gene are implicated in various cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.