Thermo Fisher Scientific Phospho-MYH9 (Ser1916) Polyclonal Antibody

Thermo Fisher Scientific Phospho-MYH9 (Ser1916) Polyclonal Antibody

Applications

• Western Blot (WB): 1:1000

Product Specifications

Product Specific Information

This antibody was cross-adsorbed to unphosphorylated Myosin IIA Heavy Chain (Ser-1916) peptide before affinity purification using phospho-Myosin IIA Heavy Chain (Ser-1916) peptide (without carrier).
The antibody detects a 200 kDa protein corresponding to Myosin IIA Heavy Chain on SDS-PAGE immunoblots of human A431 cells treated with Calyculin A.
This reactivity is removed after treatment with lambda phosphatase.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.
Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids.
This protein is part of a hexameric complex consisting of two heavy chains, two regulatory light chains, and two essential light chains.
NMHC IIA interacts with actin filaments and is involved in cell migration, adhesion, division, and maintenance of cell shape.

Mutations in MYH9 can result in autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome.
These disorders are characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.

MYH9 also plays a crucial role in hematopoiesis, essential for hematopoietic stem and progenitor cell survival.
Loss of MYH9 function disrupts normal hematopoiesis, causing severe blood cell deficiencies and bone marrow failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.