Thermo Fisher Scientific Phospho-MYH9 (Ser1916) Polyclonal Antibody
Phospho-MYH9 (Ser1916) 항체로 인간, 마우스, 랫에서 반응하며 Western blot에 최적화됨. 비인산화 펩타이드로 교차흡착 후 정제되어 높은 특이성 제공. 세포 골격 연구 및 MYH9 관련 질환 연구에 적합. 항원 친화 크로마토그래피로 정제된 고순도 제품.
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Thermo Fisher Scientific Phospho-MYH9 (Ser1916) Polyclonal Antibody
Applications
- Western Blot (WB): 1:1000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-Myosin IIA Heavy Chain (Ser-1916) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Ser-1916 in human myosin IIA heavy chain. This peptide sequence is highly conserved in rat and mouse myosin IIA heavy chain. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942947 |
Product Specific Information
This antibody was cross-adsorbed to unphosphorylated Myosin IIA Heavy Chain (Ser-1916) peptide before affinity purification using phospho-Myosin IIA Heavy Chain (Ser-1916) peptide (without carrier).
The antibody detects a 200 kDa protein corresponding to Myosin IIA Heavy Chain on SDS-PAGE immunoblots of human A431 cells treated with Calyculin A.
This reactivity is removed after treatment with lambda phosphatase.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.
Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids.
This protein is part of a hexameric complex consisting of two heavy chains, two regulatory light chains, and two essential light chains.
NMHC IIA interacts with actin filaments and is involved in cell migration, adhesion, division, and maintenance of cell shape.
Mutations in MYH9 can result in autosomal dominant disorders collectively known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome.
These disorders are characterized by macrothrombocytopenia and may lead to hearing loss, renal failure, and cataracts.
MYH9 also plays a crucial role in hematopoiesis, essential for hematopoietic stem and progenitor cell survival.
Loss of MYH9 function disrupts normal hematopoiesis, causing severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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